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Medications Used in Respiratory Pharmacology

The goal of respiratory pharmacology is to prevent or relieve the pathologic triad discussed at the beginning of this CEU module: bronchospasm, airway inflammation or mucosal edema, and retained secretions. The medicating agents used to relieve these symptoms can be referred to as the "treatment triad." The pathologic triad and treatments include:


Pathologic Condition
Treatment
Bronchoconstriction
Bronchodilator (eg., albuterol)
Airway edema
Decongestant (eg., recemic epinephrine)
Retained secretions
Hydration or mucolytics

The actions of the various categories of pharmacologic agents used to relieve the pathologic triad can be briefly summarized as:

Bronchodilators increase airway patency by relaxing the bronchial muscle spasm triggered by disease or irritation.

Decongestants cause contraction of the muscle fibers of the arterioles and small arteries, triggering a reduction of blood flow to the affected area and lowering of hydrostatic pressure that permits fluid to move into the tissues.

Mucokinetics facilitate loosening and mobilization of secretions.

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